Aminoglycoside phosphotransferase transfers phosphate moiety from ATP to the neomycin structure. Cells that have this enzyme can live with antibiotics such as kanamycin, neomycin and G418.

• IPR002575

This entry consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include:- aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation.

• 1J7I - Transferase

  Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Apoenzyme
• 1J7L - Transferase

  Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Adp Complex

  Ligand: ADP|MG
• 1J7U - Transferase

  Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Amppnp Complex

  Ligand: ANP|MG
• 1L8T - Transferase

  Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Adp Kanamycin A Complex

  Ligand: ADP|KAN|MG
• 1ND4 - Transferase

  Crystal Structure Of Aminoglycoside-3'-Phosphotransferase- Iia

  Ligand: ACT|KAN|MG|NA
• 2B0Q - Transferase

  Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Adp Neomycin B Complex

  Ligand: ADP|MG|NMY
• 2BKK - TransferaseDESIGNED PROTEIN COMPLEX

  Crystal Structure Of Aminoglycoside Phosphotransferase Aph (3')-Iiia In Complex With The Inhibitor Ar_3a

  Ligand: ADP|MG