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Aminoglycoside phosphotransferase

Aminoglycoside phosphotransferase transfers phosphate moiety from ATP to the neomycin structure. Cells that have this enzyme can live with antibiotics such as kanamycin, neomycin and G418.

EMBL-EBI/InterPro entry

This entry consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include:- aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation.

PDB entry

  • 1J7I - Transferase
    Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Apoenzyme
  • 1J7L - Transferase
    Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Adp Complex
    Ligand: ADP|MG
  • 1J7U - Transferase
    Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Amppnp Complex
    Ligand: ANP|MG
  • 1L8T - Transferase
    Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Adp Kanamycin A Complex
    Ligand: ADP|KAN|MG
  • 1ND4 - Transferase
    Crystal Structure Of Aminoglycoside-3'-Phosphotransferase- Iia
    Ligand: ACT|KAN|MG|NA
  • 2B0Q - Transferase
    Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type Iiia Adp Neomycin B Complex
    Ligand: ADP|MG|NMY
  • 2BKK - TransferaseDESIGNED PROTEIN COMPLEX
    Crystal Structure Of Aminoglycoside Phosphotransferase Aph (3')-Iiia In Complex With The Inhibitor Ar_3a
    Ligand: ADP|MG

Reference