Aminoglycoside phosphotransferase transfers phosphate moiety from ATP to the neomycin structure. Cells that have this enzyme can live with antibiotics such as kanamycin, neomycin and G418.
This entry consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include:- aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation.