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en:aminoglycoside_phosphotransferase [2013/06/09 10:09] (current)
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 +======Aminoglycoside phosphotransferase======
 +Aminoglycoside phosphotransferase transfers phosphate moiety from ATP to the neomycin structure. Cells that have this enzyme can live with [[antibiotics]] such as [[kanamycin]],​ [[neomycin]] and [[G418]].
 +
 +=====EMBL-EBI/​InterPro entry====
 +  *[[interpro>​IPR002575]]
 +
 +This entry consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include:- aminoglycoside 3'​-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3%%''​%%-kinase or streptomycin 3%%''​%%-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. ​
 +
 +=====PDB entry=====
 +  *{{pdb>​long:​1j7i}}
 +  *{{pdb>​long:​1j7l}}
 +  *{{pdb>​long:​1j7u}}
 +  *{{pdb>​long:​1l8t}}
 +  *{{pdb>​long:​1nd4}}
 +  *{{pdb>​long:​2b0q}}
 +  *{{pdb>​long:​2bkk}}
 +
 +======Reference======
 +
 +{{pubmed>​long:​2167474}}
 +
 +
 +{{tag>​antibiotics interpro}}