Standard codon code [no.1]

By default all transl_table in GenBank flatfiles are equal to id 1, and this is not shown. When transl_table is not equal to id 1, it is shown as a qualifier on the CDS feature.



Alternative Initiation Codons

In rare cases, translation in eukaryotes can be initiated from codons other than AUG. A well documented case (including direct protein sequencing) is the GUG start of a ribosomal P protein of the fungus Candida Candida albicans 1) and the GUG initiation in mammalian NAT1 2). Other examples can be found in the following references 3). The standard code currently allows initiation from UUG and CUG in addition to AUG.


Non-AUG translation initiation of mRNA encoding acidic ribosomal P2A protein in Candida albicans.
Abramczyk D, Tchórzewski M, Grankowski N
Yeast20p1045-52(2003 Sep)
Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2).
Takahashi K, Maruyama M, Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S
Genomics85p360-71(2005 Mar)
Translation initiation at non-AUG triplets in mammalian cells.
Peabody DS
J Biol Chem264p5031-5(1989 Mar 25)
High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.
Prats H, Kaghad M, Prats AC, Klagsbrun M, Lélias JM, Liauzun P, Chalon P, Tauber JP, Amalric F, Smith JA
Proc Natl Acad Sci U S A86p1836-40(1989 Mar)