Glucagon

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.

Name	Glucagon

Protein family	Glucagon/GIP/secretin/VIP
UniProt	P01275

Precursor peptide

UniProt - P01275

Peptide	Region	Length
Glicentin	21 – 89	69
Glucagon	53 – 81	29

        10         20         30         40         50         60 
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS 
                                                         ^^^^^^^^
        70         80         90        100        110        120 
DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI 
Glucagon^^ ^^^^^^^^^^ ^
       130        140        150        160        170        180 
AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK
      ^(argninie-amide after cleavage)

References

Vasoactive intestinal polypeptide and related peptides. Isolation and chemistry.
Mutt V
Ann N Y Acad Sci527p1-19(1988)

Glucagon and related peptides. Molecular structure and biological specificity.
Bataille D, Blache P, Mercier F, Jarrousse C, Kervran A, Dufour M, Mangeat P, Dubrasquet M, Mallat A, Lotersztajn S
Ann N Y Acad Sci527p168-85(1988)

Primary structure of glucagon from an elasmobranchian fish. Torpedo marmorata.
Conlon JM, Thim L
Gen Comp Endocrinol60p398-405(1985 Dec)

Mammalian pancreatic preproglucagon contains three glucagon-related peptides.
Lopez LC, Frazier ML, Su CJ, Kumar A, Saunders GF
Proc Natl Acad Sci U S A80p5485-9(1983 Sep)

Isolation of peptide hormones from the pancreas of the bullfrog (Rana catesbeiana). Amino acid sequences of pancreatic polypeptide, oxyntomodulin, and two glucagon-like peptides.
Pollock HG, Hamilton JW, Rouse JB, Ebner KE, Rawitch AB
J Biol Chem263p9746-51(1988 Jul 15)