Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
Name | Glucagon |
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Protein family | Glucagon/GIP/secretin/VIP |
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UniProt | P01275 |
Peptide | Region | Length |
---|---|---|
Glicentin | 21 – 89 | 69 |
Glucagon | 53 – 81 | 29 |
10 20 30 40 50 60 MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS ^^^^^^^^ 70 80 90 100 110 120 DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI Glucagon^^ ^^^^^^^^^^ ^ 130 140 150 160 170 180 AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK ^(argninie-amide after cleavage)