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Glucagon

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.

NameGlucagon
PubChem image 16132283

Protein familyGlucagon/GIP/secretin/VIP
UniProtP01275

Precursor peptide

UniProt - P01275

Peptide Region Length
Glicentin 21 – 8969
Glucagon 53 – 8129
        10         20         30         40         50         60 
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS 
                                                         ^^^^^^^^
        70         80         90        100        110        120 
DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI 
Glucagon^^ ^^^^^^^^^^ ^
       130        140        150        160        170        180 
AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK
      ^(argninie-amide after cleavage)

References

Glucagon and related peptides. Molecular structure and biological specificity.
Bataille D, Blache P, Mercier F, Jarrousse C, Kervran A, Dufour M, Mangeat P, Dubrasquet M, Mallat A, Lotersztajn S
Ann N Y Acad Sci527p168-85(1988)
Primary structure of glucagon from an elasmobranchian fish. Torpedo marmorata.
Conlon JM, Thim L
Gen Comp Endocrinol60p398-405(1985 Dec)
Mammalian pancreatic preproglucagon contains three glucagon-related peptides.
Lopez LC, Frazier ML, Su CJ, Kumar A, Saunders GF
Proc Natl Acad Sci U S A80p5485-9(1983 Sep)

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