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en:glucagon [2013/06/09 10:10] (current)
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 +======Glucagon======
 +Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
 +
 +{{pubchem>​l_template:​16132283|Glucagon}}
 +
 +
 +^Protein family|[[interpro>​IPR000532|Glucagon/​GIP/​secretin/​VIP]]|
 +^UniProt|[[uniprot>​P01275]]|
 +
 +=====Precursor peptide=====
 +[[uniprot>​P01275|UniProt - P01275]]
 +^Peptide ​  ​^Region ^Length^
 +^Glicentin |21 – 89|69|
 +^Glucagon ​ |53 – 81|29|
 +
 +<​code>​
 +        10         ​20 ​        ​30 ​        ​40 ​        ​50 ​        ​60 ​
 +MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS ​
 +                                                         ​^^^^^^^^
 +        70         ​80 ​        ​90 ​       100        110        120 
 +DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI ​
 +Glucagon^^ ^^^^^^^^^^ ^
 +       ​130 ​       140        150        160        170        180 
 +AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK
 +      ^(argninie-amide after cleavage)
 +</​code>​
 +
 +======References======
 +
 +{{pubmed>​long:​3133967}}
 +{{pubmed>​long:​3291691}}
 +{{pubmed>​long:​4076759}}
 +{{pubmed>​long:​6577439}}
 +{{pubmed>​long:​3260236}}
 +
 +
 +======Links=====
 +
 +  *[[insulin]]
 +  *[[cAMP]]
 +
 +
 +{{tag>​Peptide Hormone}}