Table of Contents

<select Language> bio:インスリン|日本語 bio:en:insulin|English </select>


A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Name Insulin
Protein familyInsulin-like
UniprotInsulin Precursor
MeSH 68007328
Molecular Weight 5807.57022 g/mol
Molecular Formula C257H383N65O77S6
XLogP -17.4

PubChem image 16129672


Hormone families: pancreatic hormones and homologous growth factors.
Blundell TL, Humbel RE
Nature287p781-7(1980 Oct 30)
Insulin-like growth factors I and II.
Humbel RE
Eur J Biochem190p445-62(1990 Jul 5)