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Insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Name Insulin
Ultraphane,Humuline
Protein familyInsulin-like
UniprotInsulin Precursor
MeSH 68007328
Molecular Weight 5807.57022 g/mol
Molecular Formula C257H383N65O77S6
XLogP -17.4

PubChem image 16129672

References

Hormone families: pancreatic hormones and homologous growth factors.
Blundell TL, Humbel RE
Nature287p781-7(1980 Oct 30)
Insulin-like growth factors I and II.
Humbel RE
Eur J Biochem190p445-62(1990 Jul 5)

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