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en:insulin [2013/06/09 10:10] (current)
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 +<select Language>​
 +bio:​インスリン|日本語
 +bio:​en:​insulin|English
 +</​select>​
 +
 +======Insulin======
 +A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS;​ GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
 +
 +
 +^Name| Insulin |
 +^ |Ultraphane,​Humuline|
 +^Protein family|[[interpro>​IPR016179|Insulin-like]]|
 +^Uniprot|[[uniprot>​P01308|Insulin Precursor]]|
 +^MeSH| [[MeSH>​68007328]] |
 +^Molecular Weight| ​ 5807.57022 g/mol  |
 +^Molecular Formula| <​chem>​C257H383N65O77S6</​chem>​ |
 +^XLogP| -17.4 |
 +
 +
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 +{{pubchem>​large:​16129672}}
 +
 +
 +======References======
 +
 +{{pubmed>​long:​6107857}}
 +{{pubmed>​long:​2197088}}
 +
 +
 +======Link======
 +
 +  *[[Glucagon]]
 +
 +
 +
 +
 +{{tag>​peptide hormone}}