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Nucleic acid

Ribonucleic acid is a polymer of nucleotide. The ribose-3' of nucleotide and ribose-5' of next nucleotide are bound as phophodiester bonding. There are two kinds of ribonucleic acid, DNA(deoxyribonuleic acid) and RNA(ribonucleic acid). The difference between DNA and RNA is a functional group of ribose-2' of nucleotide.

DNA

RNA

Elements

Ribonucleic acid consists of ribose, nucleobase and phophate.

Nucleobase

Modified nucleobase

These methyl group does not distub the formation of hydrogen bonding of base-pair.

Ribose

D-ribosedeoxy-D-ribose
RNA constituentDNA constituent
PubChem image 5779
PubChem image 439576

Chemistry

Alkaline catalyzed degradation of RNA

RNA degradation

Oligo-RNA tends to be degraded by base-catalytic hydrolysis in alkaline solution. RNase catalyzes this reaction without cofactors such as metal ions.

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