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en:nucleic_acid [2013/06/09 10:10] (current)
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 +<select Language>​
 +bio:​核酸|日本語
 +bio:​en:​Nucleic acid|English
 +bio:​de:​Nucleic acid|Deutcsh
 +</​select>​
 +
 +=====Nucleic acid=====
 +Ribonucleic acid is a polymer of nucleotide. The ribose-3'​ of nucleotide and ribose-5'​ of next nucleotide are bound as phophodiester bonding. ​ There are two kinds of ribonucleic acid, DNA(deoxyribonuleic acid) and RNA(ribonucleic acid). ​ The difference between DNA and RNA is a functional group of ribose-2'​ of nucleotide.
 +=====DNA=====
 +{{bio:​dna_hybridized.png}}
 +=====RNA=====
 +{{bio:​rna_hybridized.png}}
 +=====Elements=====
 +Ribonucleic acid consists of ribose, nucleobase and phophate.
 +
 +
 +====Nucleobase====
 +  *[[Nucleobase]]
 +
 +|  [[Purine]] ​ ||  [[Pyrimidine]] ​ |||
 +|  {{pubchem>​small:​1044}} ​ ||  {{pubchem>​small:​9260}} ​ |||
 +|[[Adenine]](A)|[[Guanine]](G)|[[Cytosine]](C)|[[Thymine]](T)|[[Uracil]](U)|
 +|{{pubchem>​small:​190}}|{{pubchem>​small:​764}}|{{pubchem>​small:​597}}|{{pubchem>​small:​1135}}|{{pubchem>​small:​1174}}|
 +
 +
 +
 +
 +
 +
 +
 +
 +
 +====Modified nucleobase====
 +|  [[5-Methylcytosine]] ​ |  [[6-Methyladenine]] ​ |
 +|  {{pubchem>​small:​65040}} ​ |  {{pubchem>​small:​67955}} ​ |
 +These methyl group does not distub the formation of hydrogen bonding of base-pair.
 +
 +====Ribose====
 +|D-ribose|deoxy-D-ribose|
 +|RNA constituent|DNA constituent|
 +|{{pubchem>​small:​5779}}|{{pubchem>​small:​439576}}|
 +
 +=====Chemistry=====
 +
 +====Alkaline catalyzed degradation of RNA====
 +{{ bio:​rna_degradation.png|RNA degradation}}
 +
 +Oligo-RNA tends to be degraded by base-catalytic hydrolysis in alkaline solution. [[RNase]] catalyzes this reaction without cofactors such as metal ions.
 +
 +
 +
 +
 +======Link======
 +
 +  *[[IUPAC Nucleotide Definition]]
 +
 +
 +{{tag>​Nucleic_acid}}