A pentacyclic ketolide (structurally similar to adamantane) connected by an amide bond to 3-amino-2,4-dihydroxybenzoic acid; inhibits cellular lipid biosynthesis; discovered while screening compounds from Streptomyces platensis bacteria in a South African soil sample with S. aureus bacteria deficient in FabF protein;

PubChem image 6857724

PDB image
3HNZ - Transferase
Structure Of E. Coli Fabf(C163a) In Complex With Platensimycin
Ligand: PMN

PDB image
2GFX - Transferase
Structure Of E. Coli Fabf(C163q) In Complex With Platensimycin
Ligand: PMN


Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB
Nature441p358-61(2006 May 18)
Total synthesis of platensimycin.
Nicolaou KC, Li A, Edmonds DJ
Angew Chem Int Ed Engl45p7086-90(2006 Oct 27)