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Thromboxane

One of lipid in a group of eicosanoids. It is involved in platelet aggregation.

Thromboxane A2

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).

Name Thromboxane A21)
TXA2, TXA-2
Molecular Weight 352.46508 g/mol
Molecular Formula C20H32O5
XLogP 4.2

PubChem image 5280497

Thromboxane B2

A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).

Name Thromboxane B22)
TXB2, TXB-2
Molecular Weight 370.48036 g/mol
Molecular Formula C20H34O6
XLogP 3.2

PubChem image 5283137

Reference

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
Hamberg M, Svensson J, Samuelsson B
Proc Natl Acad Sci U S A72p2994-8(1975 Aug)

1)
(Z)-7-[(1S,2S,3R,5S)-3-[(E,3S)-3-hydroxyoct-1-enyl]-4,7-dioxabicyclo[3.1.1] heptan-2-yl]hept-5-enoic acid
2)
(Z)-7-[(2R,3S,4S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]hep t-5-enoic acid